Penelitian Toksisitas Subkronik Infus Daun Johar (Cassia siamea Lamk) pada Tikus Putih

Wahjoedi, B. and Nugroho, Yun Astuti and Winarno, Winarno and Pudjiastuti, Pudjiastuti (1996) Penelitian Toksisitas Subkronik Infus Daun Johar (Cassia siamea Lamk) pada Tikus Putih. Buletin Penelitian Kesehatan, 24 (4). ISSN 0125-9695

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The Indonesia people still empirically use medicinal plants to overcome their diseases or maintain their health. One of the medicinal plants is Cassia siamea Lamk. (daun johar) used for treatment of fevers/malaria and jaundice/hepatitis. A lot of people usually use it for long periods of time. It is preferable for medicinal plants to have no effect rather than toxic effects. Subschronic toxicity test of the infusion of the leaf of Cassia Siamea Lamk, have been carried out on 72 female Wistar albino rats for4 months. The administration of the test materials were orally, every day except Sunday and there were three kinds of difference dosages respectively 25 mg/100 g b.w.; 250mg/100 g b.w. and 500 mg/100 g b.w. that means equivalent to 5 x; 25 x and 50 x usual dose of man. The control group received water only. The results showed that the infusion of the leaf of Cassia siamea Lamk. administered orally, every day until 4 months, the dose of up to 500 mg/100 g b.w. didn't show toxicological effect on the internal body organs pf the test animals such as liver, lung, spleen, kidney and intestine.

Item Type: Article
Uncontrolled Keywords: toksisitas; daun Johar; Cassia siamea Lamk.; malaria; Wistar albino; buletin penelitian kesehatan; FAR-BPPK
Subjects: QS-QZ Preclinical sciences (NLM Classification) > QY Clinical Pathology > QY 50-110 Laboratory Animals. Laboratory Techniques
Divisions: Badan Penelitian dan Pengembangan Kesehatan
Depositing User: Administrator Eprints
Date Deposited: 02 Oct 2017 05:29
Last Modified: 16 Nov 2017 04:55

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